Disease introduction: Psoriasis is a common chronic inflammatory proliferative skin disease induced by multi-gene inheritance and multi-environmental factors, which can affect about 2% of the population.

　　Experimental animals: KM mice (6-8 weeks)

　　Experimental method: 1. After the model mouse is anesthetized, prepare the skin to form an exposed area with a size of 2cm×3cm, and then use a mild depilatory cream to remove the vellus hair on the surface. Continuously apply 5% imiquimod cream to the back skin of mice to induce psoriasis. 2. Judge the model by pathological HE staining.