Disease introduction: T2DM accounts for 90-95% of the total number of diabetic patients, and brings a variety of long-term and serious complications, such as: nerve, kidney damage, blindness and heart disease, etc., bringing heavy economic benefits to society and families burden.

　　Experimental animals: SD rats, C57BL/6 mice (4-6 weeks)

　　Experimental method: 1. Feed on high-fat (high-sugar) feed for 4-6 weeks. 2. After injection of STZ, give enough water and food, change the bedding every day, and keep the squirrel cage dry. 3. Detecting blood glucose and liver pathological HE judgment model.