Disease introduction: Hypertrophic scar is the most common disease in plastic surgery, and it is also a difficult point in basic research and clinical treatment.

　　Experimental animal: New Zealand white rabbit (6-8 weeks)

　　Experimental methods: 1. Anesthetize and sterilize rabbit ears. Use a 10mm diameter trephine to make 4 circular incisions on the ventral side of each rabbit ear. The full thickness of the skin is completely removed. The periosteum separator peels off the perichondrium and retains the ear cartilage. . The scab was removed 7 days after the operation, resulting in 2 wounds. 2. Judge the model through pathological HE and Masson staining analysis.