Disease introduction: The occurrence of PMOP is closely related to the decrease of estrogen levels in postmenopausal women. It is one of the common and multiple diseases that harm the elderly.

　　Experimental animal: SD rat female (12-16 weeks)

　　Experimental method: 1. The model mouse is anesthetized to prepare the skin, and an approximately 1.5cm longitudinal surgical incision is made on the lower edge of the twelve ribs on the left and right backs. 2. Ligate around the ovary, cut off both ovaries, suture layer by layer, and disinfect the skin. 3. Detect the pathological HE judgment model.