Disease introduction: Skull defect is a common clinical problem. The current repair molding treatment has defects of varying degrees. It is necessary to develop new methods to promote the repair of skull defects.

　　Experimental animals: SD rats (6-8 weeks)

　　Experimental method: 1. After the model mouse is anesthetized, fix it, expose the skull, peel off the periosteum, use a dental drill to drill a 1cm diameter bone window in the bregma area, keep the dura mater intact, suture the incision layer by layer, and wrap it with a sterile dressing. 2. Judge the model through pathological HE staining analysis.