Disease introduction: COPD is a disease with irreversible airway remodeling caused by chronic airway inflammation as its main pathophysiological feature.

　　Experimental animals: SD rats, BALB/c mice (6-8 weeks)

　　Experimental methods: 1. After the model rats were anesthetized with inhaled isoflurane on the 1st and 14th days, LPS was injected through the tracheal intubation, and then rotated for 10-20s to make the LPS evenly distributed in the lungs. 2. Passive and continuous inhalation of smoke through the smoke generator in the airtight poison box every day from 2-13, 15-33. 3. Pathological HE staining judgment model.