动物造模,糖尿病转基因猪模型 中国实验动物信息网 2022-01-22 735

　　Diabetes (DM) is an endocrine and metabolic disorder characterized by hyperglycemia caused by absolute or relative lack of insulin in the body. It has become a global epidemic, with an incidence rate of 5% in our country. Diabetic retinopathy (diabeticetinopathy, DR) is one of the common complications of diabetes, which is increasing year by year in our country. The animal model of DM plays a major role in the study of DR, and is the basis for studying the pathogenesis, clinical manifestations, prevention and treatment of DR. It can be divided into four types: chemically induced models, spontaneous genetic animal models, partial pancreatectomy models and genetically modified organisms. Japanese researchers recently used genetic modification technology to reproduce complications such as diabetes, retinopathy, and renal failure in pigs. Reproducing these diseases in large mammals will help to study the mechanisms that cause complications and the corresponding treatments. According to "Nihon Keizai Shimbun" on the 29th, insufficient human insulin secretion can lower blood sugar levels and may lead to diabetes. High blood sugar can damage blood vessels and nerves and cause complications. In severe cases, it can cause blindness and kidney failure.

　　The research team at Meiji University in Japan used the latest genetic engineering technology to transfer the genes that cause human diabetes to pigs, thereby reducing the secretion of insulin and triggering diabetes. Prolonged feeding and observation will weaken the blood vessels of diseased pigs and continue to increase symptoms of retinal hemorrhage, cataracts and signs of kidney damage. according to

　　The research team said that previous studies on diabetes drugs mainly used experimental mice, but the weight and lifespan of experimental mice are very different from those of humans, so the effect of drug development is the effect on pigs and blood sugar levels. Mammals close to humans. The genetically modified pig model developed by the research team is more suitable for related research and helps to clarify the mechanism of diabetes and complications.