动物造模,扩张型心肌病 zi-bio 2024-02-27 319

　　Dilated cardiomyopathy is one of the main diseases causing heart failure, with etiological heterogeneity. Nearly 1/4 of patients with dilated cardiomyopathy are genetically related, with ventricular enlargement and myocardial contraction dysfunction being the main characteristics of the disease. Lamin A (LMNA) gene mutation is an important cause of hereditary dilated cardiomyopathy, and arrhythmia is an important clinical manifestation of LMNA mutated hereditary dilated cardiomyopathy.

　　In recent years, the construction and intervention of rodent dilated cardiomyopathy models based on C57/B6 genetic background mouse focused gene therapy has been a hot research topic, and there has also been some research on the construction of large animal models such as dogs and pigs. Large animals, especially non-human primates, are ideal models that are closer to humans. However, currently, the heart disease models of non-human primates do not involve dilated cardiomyopathy. Therefore, this article reviews the genetic level research on dilated cardiomyopathy in rodents and large animal models, and proposes the concept of developing non-human primate dilated cardiomyopathy models based on current research, To provide new ideas for targeted research on pathogenic mechanisms and clinical treatment in the future.