动物造模,血管性痴呆 zi-bio 2024-02-27 878

　　Vascular dementia is based on cerebrovascular disease, which means there are hemorrhagic or ischemic lesions in the brain parenchyma, with ischemia being more common. The gradual decline of cognitive ability and memory and the rising incidence rate caused by it have become a major problem affecting people's health and quality of life. Therefore, more and more scholars are starting to study the pathogenesis and prevention measures of VD. Establishing appropriate animal models for studying the mechanisms of action and efficacy evaluation of various methods of treating VD has also become a research focus in this field. On the basis of conventional modeling methods such as bilateral and four vessel occlusion, researchers have developed other improved methods to make the VD model more stable and closer to the clinical manifestations of VD.

　　On the basis of listing the improvement methods currently developed and their specific operational methods, this article introduces the advantages and disadvantages of these models and the relevant cellular and molecular mechanisms.