动物造模,结直肠癌 zi-bio 2024-02-27 871

　　Colorectal cancer is the third most common malignant tumor in the world, and the latest statistical data shows that CRC accounts for 10% of the total number of cancer cases worldwide, making it the second leading cause of cancer death. CRC is a highly heterogeneous disease, whose occurrence and development are driven by functional abnormalities or epigenetic changes caused by multiple gene expression mutations, and develop into tumors through different pathways. Due to complex factors such as genetics, environment, ethics, and individual differences among patients, the study of CRC in humans is limited. Animal disease models have become an essential tool for studying this disease, playing an important role in prevention, treatment, preclinical research, and basic research. There are various types of CRC disease models, among which mouse models are the most widely used. According to different modeling methods, they can be divided into spontaneous, chemically induced, transplanted tumor, and genetically engineered mouse models, each with its own unique characteristics and application prospects.

　　This article focuses on the CRC mouse model and introduces the latest research progress in animal models such as rats, experimental pigs, and zebrafish, in order to provide reference for the selection and application of CRC animal models.