动物造模,巨噬细胞,动物模型 zi-bio 2024-02-28 663

　　Specific fibrotic diseases of the human body and organs are one of the most serious health problems in the world, with a high mortality rate accounting for a large proportion of the world's population. Although the pathogenesis is not yet clear, its molecular pathways are complex. Chronic inflammatory cell infiltration is the most common symptom of fibrotic lesions, and recently it has been found that monocytes and macrophages are the core of inflammation and fibrosis. However, the exact mechanism by which monocytes/macrophages participate in the initiation or progression of fibrosis is still unknown. Several subpopulations of monocytes and macrophages have been identified, with specific phenotypes promoting inflammation and others exhibiting fibrotic effects. Since the demand for effective treatment of fibroproliferative diseases has not yet been met, and monocyte/macrophage subpopulations play an important regulatory role in liver fibrosis, targeted monocyte/macrophage subpopulation treatment strategies will become increasingly attractive. We will provide an overview of the cell subpopulations of monocytes/macrophages that have been identified to have a role in tissue fibrosis animal models and human systemic or organ specific fibrosis disease phenotypes. In addition, we will identify various monocyte and macrophage subpopulations by targeting phenotypic differences and design the latest methods for effective anti fibrotic treatment.