动物造模,大脑中动脉栓塞模型 zi-bio 2024-03-04 672

　　Objective: To compare the timeliness, success rate, and mortality rate of rat middle cerebral artery embolism models prepared by common carotid artery puncture and traditional thread embolization methods.

　　Method: 32 male rats were randomly divided into two groups: the common carotid artery puncture group and the traditional thread embolization group. The thread embolization was inserted from the common carotid artery to embolize the middle cerebral artery. Using the Bederson neurological function scoring system, the neurological function score was performed 24 hours after surgery, and the success rate and mortality rate at 24 hours were calculated.

　　Result: The insertion time, success rate, and mortality rate of MCAO models in rats prepared by common carotid artery puncture and traditional surgical methods were (82.3 ± 17.4) s and (164.6 ± 22.0) s, respectively, with significant differences (P<0.01); and="" with="" no="" significant="" difference="" p="">0.05); 6.25% and 18.75%, with no significant difference (P>0.05).

　　Conclusion: The common carotid artery puncture method is simple, time-saving, minimally invasive, and highly operable in preparing a rat model of middle cerebral artery embolism.