动物造模,人来源性子宫腺肌病 zi-bio 2024-03-18 582

　　Objective: To establish a nude mouse human derived adenomyosis model through different modeling methods, screen out ideal modeling methods, and provide an ideal animal model for studying the pathogenesis and related treatment plans of adenomyosis.

　　Method: 80 female nude mice were randomly divided into intraperitoneal implantation group, subcutaneous implantation group, intraperitoneal injection group, and subcutaneous injection group, with 20 mice in each group. Each model group used different modeling methods to establish nude mouse models of human derived adenomyosis, and the volume and tissue morphology of the grafts were observed 4 weeks after surgery.

　　Result: The success rate of modeling in the intraperitoneal implantation group was 95%, the success rate of modeling in the subcutaneous implantation group was 45%, and the modeling rates of intraperitoneal injection and subcutaneous injection methods were 0%.

　　Conclusion: The establishment of a nude mouse model of adenomyosis using intraperitoneal implantation has a high modeling rate and good stability, making it an ideal animal model of human derived adenomyosis.