动物造模,腹膜粘连 zi-bio 2024-03-18 784

　　Peritoneal adhesion is a product of the body's defensive response after peritoneal injury, which can occur between abdominal organs or between organs and the abdominal wall, and can cause varying degrees of intestinal obstruction, chronic pelvic and abdominal pain, infertility, etc. Previous studies have shown that over 90% of patients undergoing pelvic and abdominal surgery are prone to postoperative peritoneal adhesions, and about one-third of patients are readmitted within 10 years after surgery due to adhesions. At present, the mechanism of adhesion formation is not fully understood, and clinical and animal experiments cannot completely avoid the occurrence of adhesion. However, through extensive research, there are currently many methods to prevent the formation of peritoneal adhesion. Due to the need for reoperation in clinical practice to visually observe postoperative intra-abdominal adhesions, research on peritoneal adhesions is often replaced by experimental animals, with rats being the most commonly used. This article reviews the commonly used modeling and evaluation methods for rat peritoneal adhesions.