动物造模,慢性心肌缺血 zi-bio 2024-03-19 449

　　Objective: To explore the feasibility of a series of methods for burying needles to treat chronic myocardial ischemia in small pigs with the placement of the Ameroid constrictor ring in the left anterior descending branch during surgery?

　　Method: An Ameroid constrictor ring was placed on the left anterior descending branch of the left coronary artery in Bama miniature pigs to prepare a chronic myocardial ischemia model. The model was randomly divided into a treatment group (acupuncture at "Neiguan" point) and a control group (acupuncture at "Zusanli" point). Acupuncture was performed at "Neiguan" and "Zusanli" points respectively, followed by electroacupuncture treatment. Samples were collected after 6 weeks?

　　Result: Postoperative gross pathology showed ischemic areas in both groups. The ischemic area of acupuncture at "Zusanli" point was larger than that at "Neiguan" point. The ultrastructure of myocardial cells showed mitochondrial vacuolization in both groups? Fibrosis phenomenon?

　　Conclusion: Acupuncture at the "Neiguan" point on the pericardial meridian can protect the myocardium by reducing myocardial ischemia, but cannot inhibit existing myocardial ischemic damage? Is it feasible to establish a large experimental animal model of chronic myocardial ischemia in pigs by surgically placing an Ameroid constrictor ring on the left anterior descending coronary artery and using buried needles for treatment?