动物造模,结直肠癌,无菌鼠模型 zi-bio 2024-03-19 603

　　More and more evidence suggests that the composition of gut microbiota is closely related to the occurrence and development of colorectal cancer. Sterile animal models, especially sterile mouse models, are simple and easy to obtain, providing important tools for studying the complex relationships between microbiota, colorectal tumors, and the body. The establishment of a sterile mouse model is mainly achieved through cesarean section, sterile isolation, and breeding. On this basis, special types of sterile mouse models induced by transgenic or drug can be established according to specific research objectives. At present, sterile mouse models have been widely used in research on colorectal cancer. The research results based on sterile mouse models indicate that microorganisms or microbial communities can activate immunity and induce inflammation, thereby promoting the occurrence and development of colorectal cancer; It also proves that the imbalance of microecology and the occurrence and development of colorectal cancer are complementary and mutually causal. Due to the fact that the sterile mouse model is an important and effective research carrier for studying colorectal cancer and related diseases caused by microbial imbalance, it is worthy of further promotion and application.