动物造模,基因修饰模型 zi-bio 2024-03-19 596

　　The common soft eared tamarin is a small non-human primate experimental animal with advantages such as low breeding cost, high reproductive efficiency, and short sexual maturity time. It is very suitable for conducting assisted reproductive technology and gene modification model research.

　　The artificial assisted reproductive technology of tamarins mainly includes semen collection, superovulation, oocyte collection, in vitro maturation, in vitro fertilization, embryo culture, and transplantation. At present, research on various technologies is relatively comprehensive, but there are still details that urgently need to be improved.

　　With the rise of gene editing technology, research on gene modification of tamarins based on artificial assisted reproduction technology has gradually become a hot topic. In 2009, Japan successfully conducted research on genetically modified tamarins for the first time, and so far, there have been no reports of genetically modified tamarins in China. This article provides a review of recent advances in artificial assisted reproductive technology and genetic modification in tamarins.