动物造模,动物模型 zi-bio 2024-04-09 592

　　Objective: Based on the clinical characteristics of dizziness in traditional Chinese and Western medicine, this study classifies and analyzes existing animal models, evaluates their clinical compatibility and advantages and disadvantages, in order to improve existing animal models and provide more intuitive references for clinical research.

　　Method: Retrieve data on dizziness animal models from January 2000 to March 2023 in the database, classify them based on modeling methods, combine the clinical characteristics of dizziness in traditional Chinese and Western medicine with existing animal model evaluation methods, assign values to each model, evaluate their clinical fit, and evaluate the advantages and disadvantages of the models.

　　The existing animal models for dizziness include neck surgery model, motor stimulation model, ear derived stimulation model, sclerotherapy injection model, flight pressure change model, vertebral artery ligation model, and blood stasis injection model; Among them, the neck surgery model (65%) and ear source stimulation model (65%) have a higher degree of fit in Western medicine. All models have a moderate degree of fit (50% ≤ fit<60%) or a lower degree of fit (fit<50%), and there are no models with both high degrees of fit in Western and Chinese medicine.

　　Conclusion: Currently, the animal models for dizziness are mainly based on Western medicine disease models, lacking traditional Chinese medicine syndrome models. There are few models with high clinical compatibility between Chinese and Western medicine, which fail to highlight the characteristics of traditional Chinese medicine syndrome differentiation and treatment. Therefore, constructing a dizziness animal model closely integrated with the clinical characteristics of traditional Chinese and Western medicine can provide more reasonable and comprehensive experimental support for the development, screening, and clinical evaluation of new anti dizziness drugs.