动物造模,生理盐水致肺水肿,药效评价 z-bio 2024-06-03 621

　　1. Animal modeling materials: healthy rabbits or dogs.

　　2. Method of modeling: After anesthesia, the animal in the modeling group is cut open in the neck, separated from the skin, and intubated with the trachea, one artery, and the other vein. Normal breathing, blood pressure, and lung breathing sounds are recorded. A large amount of physiological saline is rapidly injected intravenously, at a rate of 40ml/kg per minute. Pulmonary edema can occur when the animal's total blood volume is injected 1-1.5 times.

　　3. The principle of modeling is that rapid and extensive infusion can lead to pulmonary edema in animals.

　　4. Changes after modeling Wet rales in the lungs of animals after modeling and pink foam overflow in endotracheal intubation indicate that animals have acute pulmonary edema.