动物造模,肾上腺素致家兔肺水肿,药效评价 z-bio 2024-06-04 541

　　1. Animal modeling materials: Rabbits, weighing 2.5-30kg, regardless of gender; Medications: Ulatan, adrenaline.

　　2. Method of modeling: Rabbits were anesthetized by intravenous injection of 25% Ulartan 100mg/kg into the ear margin and fixed on the operating table. Cut off the hair on the neck, separate the trachea, and perform tracheal intubation. Inject 0.4-0.6mg/kg of 1:5000 adrenaline along the ear vein of the rabbit, and the control group is not treated.

　　3. The principle of modeling is that adrenaline causes pulmonary edema in animals.

　　4. Changes after modeling: The control group had stable and rhythmic breathing, regular heart rate, normal lip and tongue mucosa, and no wet rales were heard. In the model group, 30 minutes after adrenaline, progressive dyspnea, cyanosis, pink foam like sputum overflowing from the mouth and nose, and moist rales could be heard and gradually increased.

　　The control group's lungs were full and pink, with a smooth surface and no evidence of blood stasis, and no pink fluid overflowed from the cross-section. In the model group, both lungs were significantly enlarged, swollen, blood stasis, bleeding, and there was a large amount of pink foam like liquid in the trachea, and pink liquid overflowed from the cut surface. The lung coefficient of the model group (13.5 ± 2.4) g/kg was significantly increased compared to the control group (4.9 ± 1.4) g/kg.