动物造模,肺纤维化,药效评价 z-bio 2024-06-11 579

　　1. Animal modeling materials: rats or mice; Instrument: X-ray generator.

　　2. Modeling method: The modeling animals were subjected to half chest or full body irradiation, and the mice received 11 Gy full body irradiation for 28 days; Rats received 30 Gy of half chest irradiation for 3 months.

　　3. Modeling principle: X-rays cause pulmonary fibrosis in animals.

　　4. Changes after modeling: Fibroblasts and collagen fibers proliferate around the capillaries in the alveolar wall of mice after modeling; Thick collagen fiber bundles appeared around the capillaries of rats.