动物造模,药效评价 z-bio 2024-07-01 354

　　(1) Reproduction method: Adult rats were stimulated with sulfur dioxide at a dose of (200-250) x 10 to the power of -5, for 1 hour per day and continuous stimulation for 13 days. Cold wind stimulation was used with a temperature 5 ℃ lower than the living environment temperature of the rats, for 15 minutes per day and continuous stimulation for 13 days. Wind cold stimulation was performed after the end of sulfur dioxide stimulation each time. Detect changes in respiratory rate per minute and endothelin (ET) levels.

　　(2) Model characteristics: After modeling, the number of breaths in rats significantly increased, and the plasma ET content significantly increased.

　　(3) The comparative medicine model is a multi factor model, and the model animals not only have the symptoms of the smoking method lung qi deficiency animal model, but also exhibit susceptibility, fatigue, and decreased body surface temperature.