[Animal modeling - Drug efficacy evaluation] - Dry knot constipation model

  1. Modeling material animals: Healthy Kunming mice, weighing (30 ± 2) g, both male and female.

  2. Modeling method: Mice were deprived of water and food for 72 hours, resulting in a constipation model.

  3. The principle of modeling is to establish a dry constipation model using the method of no water and no food.

  4. Changes after modeling: The weight of feces in the model animal at 12 hours was (0.0603 ± 0.0168) g, and the number of feces at 12 hours was (4.10 ± 1.10) grains.