动物造模,药效评价,脾气虚证 z-bio 2024-07-22 393

　　(1) Method of replication: Adult mice were orally administered with a dose of 0.2ml/10g body weight of raw rhubarb solution (1g of raw medicine per milliliter) twice a day for 7 consecutive days. Observe changes in mouse food intake, stool, activity, fur, body weight, etc. After the experiment, blood will be collected to measure total protein (TP) and albumin (Alb) in plasma, and swimming time will be measured.

　　(2) The model features animals with withered fur, prone to lying down, curled up, emaciated, reduced diet, thin stools, some animals with prolapse, and insignificant weight gain; The swimming time was significantly shortened, and the plasma total protein (TP) and albumin (Alb) were significantly reduced.

　　(3) Comparative medicine spleen qi deficiency syndrome refers to a weakness syndrome characterized by a weak temper and a lack of good health. Its clinical features include insufficient appetite, bloating, loose stools, and qi deficiency syndrome. According to the theory that bitter cold harms the spleen and stomach, the method of diarrhea often uses bitter cold drugs to damage the spleen and stomach of animals, leading to spleen deficiency. The most commonly used drugs in the method of bitter cold diarrhea are rhubarb, saltpeter, senna leaves, Dachengqi decoction, etc. The model replicated by this method also exhibits symptoms of injury.