动物造模,药效评价,动脉粥样硬化 z-bio 2024-07-24 410

　　Method 1

　　1. Modeling material animals: rabbits, male or female not limited; Drug: 1% Propylamine Hydrochloride.

　　2. Modeling method: Inject 1% acrylamide hydrochloride injection into the ear vein of animals at a dose of 16mg/(kg · d) for 2 consecutive weeks.

　　3. Modeling principle: Acrylamide hydrochloride causes atherosclerosis in animals.

　　After 2 weeks of modeling, proliferative changes appeared in the coronary arteries.

　　Method 2

　　1. Modeling material animals: rabbits, male or female not limited; Drug: 1% acrylamide hydrochloride, simple cholesterol.

　　2. The modeling method involves first administering 1g/kg of simple cholesterol to the animals daily for 4 consecutive weeks. After the cholesterol level rises above 1000mg/L, the animals are then intravenously injected with 1% acrylamide hydrochloride injection at a dose of 16mg/(kg · d) for 2 consecutive weeks.

　　3. Modeling principle: Acrylamide hydrochloride causes atherosclerosis in animals.

　　4. After modeling, the animal showed changes in the intimal surface of the major branches of the myocardium and the main coronary artery.