动物造模,肺心病,药效评价 z-bio 2024-07-25 345

　　1. Modeling material animals: dogs or rabbits; Drug: Anesthetic.

　　2. Modeling method: Under general anesthesia, open the chest of the dog and anastomose the descending aorta with the left pulmonary artery. The anastomotic site should be less than 1cm, and the pressure of the aorta should be used to cause simple pulmonary hypertension. Alternatively, the rabbit's trachea can be separated under local anesthesia, and a plastic wire can be used to shrink the trachea by 1/3 of its original circumference 2cm below the cricoid cartilage, and the wound can be sutured.

　　3. The principle of modeling surgery causes pulmonary heart disease in animals.

　　4. Changes after modeling: In dogs, right ventricular hypertrophy and enlargement can be observed, leading to heart failure. After more than 100 days, the model can be 100% established. High pitched wheezing sounds can be heard in the trachea of rabbits after surgery, which can create a model within 100 days.