动物造模,药效评价 z-bio 2024-07-25 370

　　1. Modeling material animal: rabbit; Medication: 5% papain solution, wild lily alkaline aqueous solution; Instrument: Nebulizer.

　　2. Modeling method: Rabbits were nebulized and inhaled with 5% papain solution, once every three months for 4 hours each time. After nebulization absorption began, wild lily alkaloids were intravenously injected at a dose of 16mg/kg once a week, for a total of 15 times.

　　3. Modeling principle: Papain can cause pulmonary heart disease in animals.

　　4. Changes after modeling: Elevated pulmonary artery pressure, right heart enlargement, lung scans, and changes in blood gas can be observed after modeling.