动物造模,支原体肺炎,药效评价 z-bio 2024-07-25 505

　　1. Modeling material animals: Wistar rats, half male and half female, with an average weight of 60g, 3 weeks old; Drug: Mycoplasma pneumoniae liquid, ether; Instrument: Syringe.

　　2. Modeling method: After a one month adaptation period, animals weighing 200-300g each will be anesthetized with ether and given a nasal drip of Mycoplasma pneumoniae bacterial solution (containing Mycoplasma pneumoniae 10 ^ 6 to 10 ^ 7 CCU/ml).

　　3. Modeling principle: Establish a model of Mycoplasma pneumoniae infection in animals.

　　4. Changes after modeling: The control group showed no thickening of the alveolar wall and no inflammatory exudate in the alveolar cavity. No obvious inflammatory lesions were observed around the small bronchi and interstitial small blood vessels in the lungs. The model group showed significant filling of capillaries within widened alveolar septa, varying degrees of infiltration of lymphoid cells, individual monocytes, and lobulated leukocytes, and significant inflammatory changes in the interstitium.