动物造模,药效评价,心动过缓 z-bio 2024-07-26 386

　　1. Modeling material animals: mice, weighing 25-40g, both male and female; Medication: 10% urinary ester, verapamil; Equipment: Biological function experimental system.

　　2. Animal modeling method: Anesthetize animals with 10% urea ester 2mg/g, and inject verapamil 8 μ g/g (concentration of 2.5mg/ml) into the tail vein.

　　3. Modeling principle: Verapamil induces arrhythmia and establishes an animal model.

　　4. After modeling and injection, there is a latent period of about 10 seconds, during which bradycardia and second or third degree atrioventricular block occur, mainly bradycardia, which can last for about 10 minutes.