动物造模,药效评价,高血压 z-bio 2024-08-19 281

　　1. Modeling material animal: SD rats, weighing 142-180g; Drug: Sucrose.

　　2. The control group was randomly fed standard feed and drank tap water; Sucrose group, freely consume standard feed, drink 10% sucrose and tap water (w/v,%). The experiment lasted for 6.5 weeks.

　　3. Modeling principle: High sugar intake can cause insulin resistance and hyperinsulinemia in SD rats, leading to an increase in blood pressure. The possible mechanism of the latter is: ① insulin induced sodium water retention; ② Stimulate increased sympathetic nerve activity; ③ The activity of Na+and Ca2+pumps on the cell membrane decreases, leading to an increase in intracellular calcium Insulin mediated changes in vascular smooth muscle tone.

　　4. Changes after modeling: The systolic blood pressure (SBP) of the model rats was (17.04 ± 0.41) p/kPa before modeling. After 3-6 weeks of molding, the pressure was (19.08 ± 0.98) p/kPa.