动物造模,药效评价,消化性溃疡 z-bio 2024-08-20 349

　　1. Modeling material animals: Male SD rats, 14 weeks old, weighing 150-200g; Medication: Ether, 1% formaldehyde solution.

　　2. Modeling method: Rats were fasted for 24 hours and deprived of water for 2 hours. After mild anesthesia with ether, the limbs and head were tied to a wooden board and vertically immersed in a water bath at (23 ± 0.5) ℃, with the water depth level at the xiphoid process. Remove after 24 hours.

　　3. Modeling principle: Stress can cause animal ulcers.

　　4. Changes after modeling: After modeling, no lesions were observed in the gastric mucosa of the normal control group; The model group showed diffuse congestion, edema, and widespread distribution of points, linear ulcers, and bleeding points, which were more common in the gastric body and pylorus.