动物造模,药效评价,消化性溃疡 z-bio 2024-08-20 279

　　1. Modeling material animals: rats, weighing 180-260g; Drug: Histamine phosphate.

　　2. Modeling method: Rats were fasted for 24 hours and subcutaneously injected with 30mg/kg of histamine phosphate in the abdomen. The injection was repeated 2 hours later, and the animals were euthanized 3 hours later.

　　3. The principle of modeling is that drugs can cause ulcers in animals.

　　4. Changes after modeling: Ulcers may occur in the esophagus, stomach, duodenum, etc. of animals after modeling.