动物造模,药效评价,肾病 z-bio 2024-08-26 347

　　1. Modeling material animals: rabbits, weighing 2-3kg; Medication: Saffron Red O, Renluo Liquid.

　　2. Modeling method: Inject 1% saffron red O solution (prepared with pre warmed 37 ℃ Renluo solution) intravenously into the modeling animal, with a total amount of 30mg, divided into two injections, with a 3-hour interval between medication.

　　3. Modeling principle: Saffron Red O induces kidney disease in rabbits.

　　4. Changes after modeling: Dyes appear in the urine of animals 2-3 hours after injection and are continuously excreted within 24 hours. The animals' appetite decreases and they refuse to eat and drink, quickly becoming weak. Some animals may experience diarrhea and difficulty breathing. The modeling is successful after 24 hours, and the experiment can be conducted within 2-10 days.