动物造模,药效评价,肾炎 z-bio 2024-08-27 274

　　1. Modeling material animals: rabbits, weighing 2-2.5kg; Drug: Cationized bovine serum albumin (C-BSA).

　　2. The modeling method used cationic bovine serum albumin (C-BSA) for intravenous injection into rabbits, 10ml each time, once a day, for a total of 5 weeks, with the dose doubled every 6 weeks.

　　3. Modeling principle: Induction of animal glomerulonephritis model by heterologous serum immune complexes.

　　After 6 weeks of medication, the glomerular diameter of the model animals was (125.3 ± 3.3) μ m, while that of the normal control animals was (89.2 ± 2.2) μ m; The number of cells in each glomerulus was (89.2 ± 3.9) in the model group and (53.4 ± 2.3) in the normal control group.