动物造模,药效评价 z-bio 2024-09-02 491

　　(1) Method of replication: Healthy domestic pigeons should be given 300-400g of copper sulfate solution at a dose of 10ml/kg body weight by gavage. After 20 minutes, the pigeons may experience reflexive vomiting.

　　(2) The model features copper sulfate used in the production process as a local emetic, which is absorbed slowly in the body. The vomiting behavior of pigeons after oral administration of copper sulfate solution is typical and easy to observe and record.

　　(3) The vomiting reaction in comparative medicine is a complex reaction of the body and a protective defense reflex. Copper sulfate, as a recognized emetic agent, has two mechanisms of emesis: peripheral and central. It can induce vomiting by stimulating the gastrointestinal mucosal receptors in animals or by stimulating the chemical sensory trigger zone at the bottom of the fourth ventricle after absorption. The vomiting model established by this method is similar to the pathogenesis of vomiting in humans, with a simple production method and short modeling time. It is an ideal animal model for studying vomiting treatment and related drug screening, especially suitable for conducting antiemetic experiments and exploring its pathogenesis.