动物造模,药效评价,抑郁症 z-bio 2024-09-25 474

　　1、 Primate mother offspring separation model

　　Some primates or non primates may exhibit characteristic symptoms such as agitation, sleep disorders, and lamenting after separation from their offspring. The content of neuropeptides in the brains of young children is significantly reduced, which can easily cause emotional changes and lead to some of the main symptoms of depression. In the following 1-2 days, there will be active or passive physical reactions. This model is only used as a preliminary screening for some antidepressants.

　　2、 Orphaned chicken animal model

　　Chicks are accustomed to living in groups. When social chicks are fed individually, they will feel lonely and often cry out afterwards. This kind of cry can be considered a major symptom of depression. When given antidepressants, their crying symptoms can be significantly reduced. This model is commonly used for the initial screening of antidepressants.

　　3、 Animal models such as male female separation of paired hamsters and solitary care of social rats

　　These animal models also exhibit some symptoms of depression, such as reduced spontaneous activity. For example, when young rats are separated from their mothers before weaning and isolated for 10-12 months, these isolated rats exhibit generally increased activity and other behavioral changes such as rodent killing behavior compared to group fed rats. Due to the fact that excessive activity in isolated rats can be selectively countered by various antidepressants, it can be considered as an ideal animal model for screening antidepressants. However, the experimental period is long and difficult to apply universally.