陈玲玲 z-bio 2024-12-02 691

　　From initially serving as a medium for information transmission between DNA and proteins, to the later discovery of various non coding RNAs (ncRNAs), RNA's functions far exceeded initial imagination. Among all RNA, ncRNA accounts for as much as 98%.

　　In recent years, it has been gradually discovered that a large number of non coding RNAs play critical roles in gene expression regulation, cell signaling, chromosome structure maintenance, and various biological processes. In this dynamic research field, researcher Chen Lingling from the University of Chinese Academy of Sciences stands out with her outstanding research achievements.

　　This year, she won the second prize of the the State Natural Science Award (the first person to complete it) by virtue of "Research on the generation and functional mechanism of cyclic RNA"; Later, he was awarded the Excellence Research Award by the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) in 2024, becoming the third Chinese scientist to receive this award after Academicians Shao Feng and Yan Ning.

　　Chen Lingling, born in Shangqiu, Henan Province in December 1977, is currently a researcher, research leader and doctoral supervisor of the Center of Excellence in Molecular Cell Science of the Chinese Academy of Sciences. Currently serving as an editorial board member for multiple international journals such as Cell, Science, Mol Cell, as well as the chairman of conferences such as the Cold Spring Harbor Laboratory Non Coding RNA Conference and the International RNA Association Annual Meeting. In 2017, he was selected as an international research scholar by the Howard Hughes Medical Institute (HHMI) and supported by the National Science Foundation for Distinguished Young Scholars. Has won honors such as the China Youth Science and Technology Award Special Award, Science Exploration Award, Tan Jiazhen Life Science Innovation Award, Global Chinese Biologists Association CBIS Young Researcher Award, and China Young Female Scientist Award.

　　Growth: Racing against Time

　　Chen Lingling received her bachelor's degree from Lanzhou University in 2000 and her master's degree from the Chinese Academy of Sciences Shanghai Institute of Materia Medica in 2003. Subsequently, he went to the University of Connecticut in the United States for further studies and obtained a Ph.D. in Biomedical Sciences in 2009, as well as a Master's degree in Business Administration from the School of Business.

　　In May of the same year, as an independent PI, I was awarded the Connecticut Stem Cell Seed Award research funding. I was employed as a postdoctoral researcher at the School of Stem Cells at the University of Connecticut and became an assistant professor in May 2010.

　　In 2011, Chen Lingling still decided to return to China and join the Center for Excellence and Innovation in Molecular Cell Science (the former Institute of Biochemistry and Cell Biology) of the Chinese Academy of Sciences. Starting from scratch, she recruited a team, applied for funding, and led the team to explore and discover various new long non coding RNA families that play important regulatory roles in life activities internationally.

　　It is worth mentioning that in May 2017, Researcher Chen Lingling won the Howard Hughes Medical Institute International Young Scientist Award, indicating that she has become a leader in this field on the global scientific stage.

　　In August of the same year, an application titled "Metabolism and Function of Long Non coding RNAs" was successfully funded by the National Science Foundation for Distinguished Young Scholars.

　　During the study period, conduct experiments during the day and learn management at night; After engaging in scientific research, there are almost no weekends. Even the day before giving birth, I was still working... and it was this relentless journey that led to today's extraordinary achievements.

　　She once said, "There are no shortcuts to doing scientific research. There is only so much time, and only by working hard can one do it faster and better than others

　　Exploration: Interpreting the Book of Life

　　Chen Lingling's team has long focused on cutting-edge research in the fields of long non coding RNA and circular RNA, including the discovery of new types of molecules, their processing and maturation mechanisms, their functions in transcription, chromosomes, nuclear substructures, and stem cell stemness maintenance, as well as related application potential.

　　On the occasion of the 50th anniversary of the founding of Cell magazine this year, Chen Lingling was invited to collaborate with V. from Seoul National University in South Korea Professor Narry Kim collaborated to publish a lengthy review article titled "Small and long non coding RNAs: Past, Present, and Future" in this top tier journal on November 14th. This article systematically reviews the discovery process, mechanism of action, research progress, and functional cognition of these two non coding RNAs in physiology and pathology, and looks forward to future research directions in the field of non coding RNAs.

　　Previously, she was invited to publish a review paper titled "Dynamic conformation: Marching towards circular RNA function and application" as the corresponding author in Molecular Cell. The paper summarized the influencing factors and mechanisms of circular RNA conformation, as well as the existing technical means and bottlenecks in research, further indicating that these efforts will ultimately provide guidance for designing circular RNA platforms for biomedical applications.

　　On October 23rd, Researcher Chen Lingling was invited as the sole author to publish a review article in One of the Four Top Clinical Medicine Journals, The New England Journal of Medicine.

　　This article provides an in-depth interpretation of a research collaboration between the Massachusetts Institute of Technology and the Broad Institute at Harvard University (Neurodevelopmental Disorder Caused by Deletion of CHASERR, a lncRNA Gene), exploring the issue of insufficient non coding RNA dosage leading to neuroimmune diseases and pointing out future research directions.

　　This is the first Chinese scholar invited by the "Science Behind the Study" section of NEJM magazine.

　　Upon closer inspection, Researcher Chen Lingling has been invited to publish four review articles in four different top tier journals this year, demonstrating the recognition of her research capabilities.

　　In addition, their team has published multiple high-level articles in journals such as Nature Biotechnology, Nature Methods, Molecular Cell, etc. this year, and Researcher Chen Lingling is an independent corresponding author.

　　As one of the earliest scholars in China to study long non coding RNAs, Chen Lingling has been pursuing the latest technology and exploring more unknowns. The development of third-generation long read RNA sequencing technology, ultra-high resolution microscopy imaging technology, as well as gene editing and base editor technology, is bringing unprecedented opportunities for analyzing new mechanisms of RNA action and new applications of RNA based on original theories. "She emphasized," Time waits for no one. We must carry forward the spirit of daring to be the first and make every effort to seize the technological high ground in this field

　　Can she be successfully elected next year as a valid candidate for the co selection of academicians of the Chinese Academy of Sciences for two consecutive terms?