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[Animal modeling]-Intervention effect and mechanism of down-regulation of miR-192 on renal interstitial fibrosis in rats with unilateral ureteral obstruction

[Animal modeling]-Intervention effect and mechanism of down-regulation of miR-192 on renal interstitial fibrosis in rats with unilateral ureteral obstruction

To investigate the effect of down-regulation of miR-192 expression on renal interstitial fibrosis in rats with unilateral urinary tract obstruction (UUO) and its mechanism...

2020-09-10
【Animal Modeling】-Coptis Rhizoma Polysaccharides Reduce Kidney Injury in Diabetic Rats by Inhibiting Oxidative Stress and Inflammation

【Animal Modeling】-Coptis Rhizoma Polysaccharides Reduce Kidney Injury in Diabetic Rats by Inhibiting Oxidative Stress and Inflammation

To study the protective effect and potential mechanism of Rhizoma Coptidis polysaccharide on nephropathy in diabetic rats...

2020-09-10
[Animal Modeling]-Application of Nile Red Tracer Nanoformulation in In vivo Imaging of Tumor-bearing Nude Mice

[Animal Modeling]-Application of Nile Red Tracer Nanoformulation in In vivo Imaging of Tumor-bearing Nude Mice

How to wrap Nile Red in nano-specimen and use its fluorescence characteristics to study the tumor targeting of tumor-bearing mice and the tissue distribution of nano-specimen?...

2020-09-10
[Animal Modeling]-Can flip coins replace animal experiments?

[Animal Modeling]-Can flip coins replace animal experiments?

Researchers in Berlin, Germany, did not repeat experiments on mouse disease models in the laboratory, but instead used Cointos to see if the drug could protect the brain from stroke...

2020-09-10
【Animal Modeling】-The effect of high-fat food and K/BxN serum on the immune system of ApoE knockout mice

【Animal Modeling】-The effect of high-fat food and K/BxN serum on the immune system of ApoE knockout mice

To detect the effects of high-fat diet and K/BxN serum on the distribution of immune cells in ApoE knockout (ApoE-/-) mice...

2020-09-10
[Animal Modeling]-Effect of Astragalus on Endoplasmic Reticulum Stress Response in Vascular Remodeling in Hypertensive Rats

[Animal Modeling]-Effect of Astragalus on Endoplasmic Reticulum Stress Response in Vascular Remodeling in Hypertensive Rats

To study the effect of Astragalus on endoplasmic reticulum stress response in vascular remodeling in hypertensive rats, and to explore the molecular mechanism of its vascular protection?...

2020-09-10
[Animal Modeling]-The protective effect of curcumin on renal fibrosis in a mouse model of chronic kidney disease induced by 5/6 kidney ligation

[Animal Modeling]-The protective effect of curcumin on renal fibrosis in a mouse model of chronic kidney disease induced by 5/6 kidney ligation

To study the protective effect of curcumin on renal fibrosis in chronic kidney disease (CKD) and explore the possible mechanism?...

2020-09-10
【Animal Modeling】-The effect of dexmedetomidine on rat sciatic nerve

【Animal Modeling】-The effect of dexmedetomidine on rat sciatic nerve

Peripheral nerve block is often used for postoperative pain and surgical anesthesia. Long-acting local anesthetics have an analgesic effect of 9-14 hours....

2020-09-10
[Animal Modeling]-The antidepressant effect of coumarin on chronic unpredictable mild stress mice

[Animal Modeling]-The antidepressant effect of coumarin on chronic unpredictable mild stress mice

How to observe the antidepressant effect of Kieran and explore its possible mechanism in advance?...

2020-09-10
【Animal Modeling】-The inhibitory effect of geraniol on the central nervous system of rats

【Animal Modeling】-The inhibitory effect of geraniol on the central nervous system of rats

Geraniol is an important part of essential oils, such as ginger, lemon, lime, lavender, nutmeg, citrus and rose...

2020-09-10
[Animal modeling]-Capsaicin activates receptors on the surface of mammalian pain-sensitive cells

[Animal modeling]-Capsaicin activates receptors on the surface of mammalian pain-sensitive cells

Muzzle-a kind of whistling food that leads to pure consumption, called hellish burning...

2020-09-09
【Animal Modeling】-Aspirin\'s Mechanism of Controlling Salt Sensitive Hypertension in Rats

【Animal Modeling】-Aspirin\'s Mechanism of Controlling Salt Sensitive Hypertension in Rats

Explore the regulatory effect of aspirin on related mechanisms in salt-sensitive hypertensive rats?...

2020-09-09
【Animal Modeling】-The effect of maca combined with exercise therapy on the activity of respiratory chain enzymes in kidney mitochondria and renal function of diabetic rats

【Animal Modeling】-The effect of maca combined with exercise therapy on the activity of respiratory chain enzymes in kidney mitochondria and renal function of diabetic rats

How to observe the effect of maca combined with exercise therapy on mitochondrial respiratory enzyme activity and renal function of diabetic rats...

2020-09-09
[Animal Modeling]-Effects of repeated propofol anesthesia on spatial memory and long-term enhancement of young rats under hypoxic conditions

[Animal Modeling]-Effects of repeated propofol anesthesia on spatial memory and long-term enhancement of young rats under hypoxic conditions

Propofol is the most commonly used intravenous induction and maintenance anesthesia. Hypoxemia is a common complication during anesthesia...

2020-09-09
【Animal modeling】-The efficacy and safety of new naltrexone in the treatment of type 1 diabetic dry eye

【Animal modeling】-The efficacy and safety of new naltrexone in the treatment of type 1 diabetic dry eye

Tear-deficient dry eye disease (TDDE) or aqueous dry eye disease (DED) refers to abnormal tear secretion related to pathophysiology and/or environmental factors. It is a multifactorial disease characterized by changes in the volume of the tear film a...

2020-09-09
[Animal Modeling]-Re-encoding of human pancreatic islet cells can relieve diabetes in mice

[Animal Modeling]-Re-encoding of human pancreatic islet cells can relieve diabetes in mice

Humans can recode human alpha and gamma islet cells to produce insulin...

2020-09-09