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【Animal Modeling】-Non-alcoholic fatty liver disease cynomolgus monkey model induced by high-fat diet

【Animal Modeling】-Non-alcoholic fatty liver disease cynomolgus monkey model induced by high-fat diet

Establish an animal model of non-alcoholic fatty liver disease induced by high-fat diet, analyze the effect of high-fat feed feeding time on the formation of animal NAFLD, and study the high-fat feed feeding time...

2021-02-22
【Animal Modeling】-Making rabbit myocardial infarction model with minimally invasive cardiac catheterization technique

【Animal Modeling】-Making rabbit myocardial infarction model with minimally invasive cardiac catheterization technique

To explore the application of cardiac catheterization technique in occluding coronary arteries to establish rabbit myocardial infarction (MI) model...

2021-02-22
Type 2 diabetes rat model: assessing the permeability of the blood-brain barrier

Type 2 diabetes rat model: assessing the permeability of the blood-brain barrier

This is an exploration that uses new imaging methods, quantitative ultra-short echo time and contrast agent (QUTE-CE) magnetic resonance imaging to evaluate the permeability of the blood-brain barrier in a rat model of type 2 diabetes...

2021-02-22
【Animal Modeling】-NASH mouse model selection guide for non-alcoholic fatty liver

【Animal Modeling】-NASH mouse model selection guide for non-alcoholic fatty liver

Non-alcoholic fatty liver disease is a disease in which too much fat is stored in the liver...

2021-02-22
【Animal Modeling】-Intraperitoneal injection of different doses of cisplatin to establish a model of premature ovarian failure induced by chemotherapy

【Animal Modeling】-Intraperitoneal injection of different doses of cisplatin to establish a model of premature ovarian failure induced by chemotherapy

To explore the method of establishing chemotherapy-induced primary ovarian insufficiency (POF) rat model by intraperitoneal injection of different doses of cisplatin (CP)...

2021-02-22
【Animal Modeling】-Establishment of Salt Sensitive Hypertension Mouse Model

【Animal Modeling】-Establishment of Salt Sensitive Hypertension Mouse Model

Establish a salt-sensitive hypertensive mouse model and verify the model with the antihypertensive drug nifedipine...

2021-02-22
【Animal Modeling】-Construction of inhibin gene knockout mouse model and preliminary analysis of phenotype

【Animal Modeling】-Construction of inhibin gene knockout mouse model and preliminary analysis of phenotype

Use clustering, regularly spaced short-interval palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9)] gene editing technology to construct an inhibin knockout mouse model for preliminary phenotype analysis...

2021-02-22
[Animal Experiment]-The new model predicts that larger fish will suffer respiratory distress faster

[Animal Experiment]-The new model predicts that larger fish will suffer respiratory distress faster

A new study conducted by researchers from Radboud University in collaboration with international researchers from McGill University (Canada) and University of Montana (USA) shows that big fish have more difficulty breathing in warm water than small f...

2021-02-21
[Animal Experiment]-Probiotics reduce anxiety-related behaviors in zebrafish

[Animal Experiment]-Probiotics reduce anxiety-related behaviors in zebrafish

The increasing use of probiotics has broadened our knowledge of the effects of intestinal microbial components and bacterial metabolites on neurological and behavioral processes through different regulatory pathways....

2021-02-21
【Animal experiment】-Zebrafish kit ligand and erythropoietin synergistically promote the proliferation of erythroid cells

【Animal experiment】-Zebrafish kit ligand and erythropoietin synergistically promote the proliferation of erythroid cells

The most important cytokines that regulate the proliferation and differentiation of vertebrate red blood cells are erythropoietin (EPO) and KIT ligand (KITLG; or stem cell factor)...

2021-02-21
[Animal Modeling]-The main vault protein is not necessary for zebrafish organ regeneration

[Animal Modeling]-The main vault protein is not necessary for zebrafish organ regeneration

The evolutionarily highly conserved major vault protein (MVP) is the main component of the largest naturally occurring ribonucleoprotein...

2021-02-21
Zebrafish Model: Deciphering the Cellular State and Plasticity of Melanoma

Zebrafish Model: Deciphering the Cellular State and Plasticity of Melanoma

  Dynamic cell heterogeneity is the cause of melanoma progression and treatment resistance. Advances in single-cell technology have revealed more and more tumor and microenvironmental cell states in melanoma, but little is known about their function ...

2021-02-21
Breakthrough gene therapy can treat deadly heart disease

Breakthrough gene therapy can treat deadly heart disease

A study funded by the British Heart Foundation (BHF) showed that newly discovered genetic defects in heart disease patients can be passed on to family members, thereby changing the diagnosis and treatment of the disease...

2021-02-21
The effect of overexpression of bone morphogenetic protein 4 on the proliferation and chondrogenesis of rabbit bone marrow mesenchymal stem cells

The effect of overexpression of bone morphogenetic protein 4 on the proliferation and chondrogenesis of rabbit bone marrow mesenchymal stem cells

To study the effect of adenovirus (Ad) vector infection and bone morphogenetic protein 4BMP-4 overexpression on the proliferation and cartilage formation of rabbit bone marrow mesenchymal stem cells (BMSC) in vitro...

2021-02-21
Deciphering the fine structure of coronavirus s protein provides new ideas for vaccines

Deciphering the fine structure of coronavirus s protein provides new ideas for vaccines

Recently, a team composed of Professor Peng Guiqing from the State Key Laboratory of Agricultural Microbiology of Huazhong Agricultural University and Shanghai University of Science and Technology analyzed the atomic degradation structure of the surf...

2021-02-21
[Animal modeling] -O-N-acetylglucosamine glycosylation level positively regulates the expression of angiopoietin-2 to promote tumor angiogenesis in mouse liver cancer

[Animal modeling] -O-N-acetylglucosamine glycosylation level positively regulates the expression of angiopoietin-2 to promote tumor angiogenesis in mouse liver cancer

To explore the relationship between O-N-acetylglucosamine (O-GlcNAc) glycosylation level and the expression of Angiopoietin-2 (Ang-2) in the process of liver cancer...

2021-02-21