国家杰青,国自然 z-bio 2025-09-18 3187

　　Recently, the National Natural Science Foundation of China announced the project approval of the outstanding research group project in 2025. Professor Wang Yanjiang from the Department of Neurology, Army Special Medical Center of the Army Medical University, led by Professor Wang Yanjiang of the National Natural Science Foundation of China Excellent Research Group Project (Class B) jointly applied for by Fudan University and Xiamen University, "Analysis of Complex Mechanisms of Alzheimer's Disease and Innovative Diagnosis and Treatment Exploration" after meeting review and on-site inspection, it was officially approved and approved with a funding of 60 million yuan. It is the first outstanding research group project led by Chongqing.

　　Alzheimer's disease (AD) is a major disease that endangers the health of the elderly. It has the highest incidence rate. There is currently a lack of early diagnosis and effective intervention methods. The main reason is that its mechanism of occurrence is unclear. The project takes the "complex systematic mechanism hypothesis" of Alzheimer's disease as its idea, and takes the clinical and community cohort of Alzheimer's disease as its main research objects. Through the integrated analysis of multiomics, multimodal, and multidimensional data, it analyzes the complex mechanisms of Alzheimer's disease from a systematic perspective, screens out early diagnostic marks and intervention targets, establishes early diagnosis and accurate diagnostic methods, and develops innovative treatment technologies and drugs targeting cognitive function improvement. The goal is to make original breakthroughs in key areas such as the pathogenesis, blood diagnosis and cognitive protection of Alzheimer's disease, and provide effective solutions to the increasingly severe Alzheimer's disease challenge.

　　The project leader Professor Wang Yanjiang, who has been engaged in Alzheimer's disease research for a long time, has received funding from the National Outstanding Youth Science Foundation and has been selected as an outstanding scientist in Chongqing. The backbone of the project includes Professor Yujintai, a well-known scholar in the field of clinical, basic and medical engineering research at Fudan University, Professor Zhang Jiayi, the Institute of Brain Science, Fudan University, Professor Zhang Yunwu and Professor Wang Xin, the Institute of Neuroscience, Xiamen University, to form an innovative team with interdisciplinary disciplines. The project team has focused on Alzheimer's disease for more than 20 years and has made a series of innovative discoveries in the occurrence mechanism, early diagnosis and intervention strategies of Alzheimer's disease. The research results have been published in journals such as Science and Cell. They have successively won the first prize, second prize, New Cornerstone Science Exploration Award, Chongqing Natural Science First Prize and Alzheimer Award, laying a solid foundation for the implementation of this project.

　　The Army's Specialty Medical Center took the lead in the approval of the National Natural Science Foundation's Excellent Research Group Project, which is not only a milestone breakthrough for the school in the field of neurodegenerative diseases research, but also a concrete practice of the majority of scientific and technological workers to thoroughly implement the important instructions of President Xi on "Caring the Peak of Military Medicine" when he visited the university. In the future, the team will continue to tackle the key points in Alzheimer's disease mechanism analysis and diagnosis technology and prevention and treatment strategies, produce more internationally leading original results, and make contributions to the realization of the "Healthy China 2030" plan outline goals.