z-bio 2025-11-06 3132

　　As a valid candidate for the 2025 academician election of the Chinese Academy of Engineering and the president of Qilu Hospital of Shandong University, the team led by Professor Chen Yuguo has been deeply involved in the field of emergency and critical care for a long time. Recently, it has published four blockbuster studies in authoritative international journals such as Cell Reports Medicine and Resuscitation, covering key directions such as optimization of cardiopulmonary resuscitation and analysis of the mechanisms of vascular diseases, injecting Chinese power into global emergency and critical care treatment.

　Focus on clinical pain points: two studies optimize cardiopulmonary resuscitation strategies

　　Core findings: For the first time, gender differences in the implementation of cardiopulmonary resuscitation for OHCA patients in my country have been systematically revealed. It is clear that the probability of young women aged 18-44 years receiving bystander cardiopulmonary resuscitation is significantly lower than that of men, and remote guidance by dispatchers can effectively eliminate this gap. This study provides precise optimization targets for my country's first aid training system and helps improve the accessibility and fairness of first aid for different gender groups.
      Corresponding author: Professor Chen Yuguo, Professor Xu Feng, first author’s unit: Emergency Department, Qilu Hospital of Shandong University
      2. Paper title: Combined End-Tidal CO2 and Diastolic Blood Pressure–Guided CPR Improves Survival from Cardiac Arrest

　　Core discovery: The first "end-tidal CO₂ + diastolic blood pressure" dual-indicator real-time feedback guidance program breaks through the limitations of the traditional fixed-parameter resuscitation model. In the cardiac arrest pig model experiment, this solution not only significantly improved the 24-hour survival rate and neurological function recovery level, but also optimized key hemodynamic indicators such as coronary perfusion pressure and mean arterial pressure during the resuscitation process, providing a practical technical path for individualized cardiopulmonary resuscitation. The research was completed based on a self-developed high-precision fully automatic chest compression device, which is an important breakthrough in the cross-integration of medicine and industry.

　　Corresponding authors: Professor Chen Yuguo, Professor Xu Feng, Professor Li Ke, School of Control Science and Engineering, Shandong University, first author: Jiang Tangxing, Sun Yijun, Zhang Huidan, doctoral candidates in the Emergency Department of Qilu Hospital

　　Digging deeper into disease mechanisms: Unlocking new targets for precise treatment of vascular diseases

　　In response to the international problem of vascular diseases, the team published two mechanism studies in high-scoring journals, laying the foundation for drug research and development.

　　1. Paper title: Targeting USP21 to Inhibit Abdominal Aortic Aneurysm Progression by Suppressing the Phenotypic Transition of Vascular Smooth Muscle Cells

　　Journal published: "Cell Reports Medicine" (IF=11.7)

　　Core discovery: For the first time, it was confirmed that the deubiquitinating enzyme USP21 is a key cancer-promoting target in the progression of abdominal aortic aneurysm. By binding to the ALDH2 protein and removing its ubiquitin chain modification, it regulates the phenotypic conversion of vascular smooth muscle cells and aggravates aneurysm formation. Combined with the "red face gene" carried by 30%-50% of Chinese people, the team verified that the FDA-approved drug disulfiram can alleviate disease progression by inhibiting USP21 activity and provide a new personalized treatment strategy for abdominal aortic aneurysms.

　　Corresponding author: Professor Chen Yuguo, Professor Xu Feng, first author’s unit: Emergency Department, Qilu Hospital of Shandong University

　　2. Paper title: ALDH2 deficiency aggravates vascular injury-induced restenosis by enhancing vascular smooth muscle cell proliferation through SLC38A2-mediated upregulation of glutamine uptake

　　Journal published: "Metabolism" (IF=11.9, Chinese Academy of Sciences District 1 TOP)

　　Core discovery: It was revealed for the first time that ALDH2 gene variation enhances glutamine uptake through the 4-HNE-ATF4-SLC38A2 regulatory axis, promotes the proliferation and migration of vascular smooth muscle cells, and ultimately aggravates restenosis after coronary intervention. This study provides precise intervention directions for the prevention and treatment of restenosis in East Asian populations with high ALDH2 variant carriers, and also explains the association between this gene variant and poor prognosis in patients with acute coronary syndrome from a mechanistic level.

　　Corresponding author: Professor Chen Yuguo, Professor Xu Feng, first author: doctoral student Hou Dehui and assistant researcher Yang Kehui from Qilu Hospital of Shandong University

　　Building a Chinese system: Scientific research results are implemented into clinical practice

　　The team adheres to the "clinical-basic-translational" research model. The BASIC cohort led by it covers more than 70 medical units across the country and has a survey population of over 100 million. It is the largest cardiac arrest registration study in developing countries. Research results have been transformed into clinical effectiveness, and related technologies are widely used in front-line treatment. At the same time, it takes the lead in drafting national standards and participates in the compilation of international consensus. The output of the series of top publications not only demonstrates my country's scientific research strength in the field of critical care, but also provides solid support for improving the treatment rate of cardiac arrest and reducing the death and disability rate of cardiovascular disease through innovative exploration focusing on the characteristics of the Chinese population, and contributes to the advancement of the Healthy China strategy.

　　Introduction to Professor Chen Yuguo: