z-bio 2025-11-27 3933

　　Researcher Gao Yue is currently the director of the Pharmacology and Toxicology Research Office of the Institute of Radiation and Radiation Medicine, Academy of Military Medical Sciences, and concurrently the director of the Military Key Laboratory of Traditional Chinese Medicine and Natural Medicine Research. He has been engaged in military pharmacy, traditional Chinese medicine pharmacology and toxicology research for 36 years. He was elected as an academician of the Chinese Academy of Engineering in November this year. She led the team to create a supporting key technology platform for traditional Chinese medicine safety research, and the new technology system formed was successfully used to confirm the toxic components of traditional Chinese medicine, analyze the toxic mechanism, demonstrate classic theories, and develop innovative drugs, and achieved fruitful scientific research results.

　　1. Engineering (IF 11.6), thesis title Safety Research in Traditional Chinese Medicine: Methods, Applications, and Outlook

　　Core highlights: Although traditional Chinese medicine has more than 2,000 years of clinical experience and has formed a theoretical system such as the properties and compatibility of traditional Chinese medicine, the safety issues of traditional Chinese medicine have seriously hindered its modernization and internationalization process. Gao Yue led the team to establish a key technology system for toxicity evaluation that integrates modern science and technology with the characteristics of traditional Chinese medicine: early toxicity discovery technology, dose-toxicity relationship identification method, comprehensive research technology for traditional Chinese medicine interactions, and molecular toxicology technology platform. At present, this technical system has been verified in the incompatibility of traditional Chinese medicines, quality control, allergen discovery, and the study of the toxicity mechanisms of specific traditional Chinese medicines such as Sophora indica, Cassia seed, Polygonum multiflorum, and Psoralen.

　　Author information: Academician Gao Yue is the first author and corresponding author. The core completion units are: Institute of Radiation Medicine, Academy of Military Medical Sciences, Institute of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, School of Pharmacy, Zhejiang University, and School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine.

　　2. Signal Transduction and Targeted Therapy (IF 52.7) paper title Potential benefits of precise corticosteroids therapy for severe 2019-nCoV pneumonia

　　Core highlights: This article, published in the early stages of the epidemic, discussed the then controversial value of corticosteroids in the treatment of patients with severe novel coronavirus pneumonia (COVID-19). Researchers, working with frontline ICU medical staff in Wuhan, discovered for the first time that corticosteroids can increase patients' oxygenation index and blood oxygen saturation, help suppress excessive inflammatory responses during the ARDS stage, and buy valuable time to control infection and prevent multi-organ function damage. Based on the limited evidence and clinical experience at the time, the researchers proposed that low-dose corticosteroids were a reasonable adjuvant treatment strategy for some severe COVID-19 patients. After the article was published, its core ideas were verified in large-scale clinical trials.

　　Author information: Academician Gao Yue is the corresponding author. The core completion units are: Institute of Radiation Medicine, Academy of Military Medical Sciences, School of Nursing, Capital Medical University, Hebei Provincial People's Hospital, First Medical Center of the Chinese People's Liberation Army General Hospital, Second Affiliated Hospital of Zhejiang University School of Medicine, Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, and Wuhan Pulmonary Hospital.

　　3. Nature Communication (IF 15.7) Thesis title: Inhibition of UBA6 by inosine augments tumor immunogenicity and responses

　　Highlights of the paper: Although immune checkpoint blockade therapy (ICB) has changed the landscape of cancer treatment, drug resistance remains a major challenge. Gao Yue's team and the Yuan Xiangliang/He Baokun team from Shanghai Jiao Tong University School of Medicine found that the purine metabolite inosine directly regulates ubiquitin-like modification activating enzyme 6 (UBA6) in tumor cells, enhancing tumor immunogenicity and providing new ideas for overcoming ICB resistance. UBA6 is expected to become a new biomarker for predicting the efficacy of immunotherapy. Inosine itself is a drug that has been used clinically (adjuvant treatment of chronic hepatitis) and has high safety, which will facilitate subsequent clinical translation.

　　Author information: Academician Gao Yue, Professor Yuan Xiangliang, and Professor He Baokun are the co-corresponding authors. Core units: Shanghai Jiao Tong University School of Medicine, Guangzhou University of Traditional Chinese Medicine, Capital Medical University, University of Texas MD Anderson Cancer Center, Institute of Radiation Medicine, Academy of Military Medical Sciences.

　　4. Chemical Engineering Journal (IF 13.2) Paper title: Constructing multilayered WB2/Bi/poly(ethylene-co-1-octene) composites with excellent nuclear radiation shielding efficiency and radiation damage prevention

　　Highlights of the paper: While nuclear technology brings huge benefits, the nuclear radiation it releases also poses a serious threat to operators. The application of traditional lead shielding materials is limited due to toxicity, heavy weight and lack of flexibility. The team innovatively prepared a multi-layer composite structure in which WB2/POE and Bi/POE are alternately distributed, so that when radiation passes through the material, it can scatter and absorb multiple times between different layer interfaces, thereby significantly improving the overall shielding efficiency. This research not only successfully developed a new multi-layer nuclear radiation shielding composite material, but also found that chromosome methylation level can be used as a sensitive indicator to detect the biological effects of low-dose radiation, contributing a new detection method to the field of radiation protection.

　　Author information: Academician Gao Yue, Associate Researcher Zhou Wei, and Associate Researcher Zhang Xianlong are the co-corresponding authors. Core units: Institute of Polymer Research, Sichuan University, Institute of Radiation Medicine, Academy of Military Medical Sciences

　　5. Genomics Proteomics & Bioinformatics (IF 11.5) Thesis title: Plasma Proteomic Profiling Reveals ITGA2B as A Key Regulator of Heart Health in High-altitude Settlers

　　Highlights of the paper: The low-pressure hypoxic environment at high altitude can easily induce myocardial cell damage, leading to group cardiomyopathy and heart failure. The academic community's scientific understanding and intervention strategies of high-altitude myocardial injury need to be further deepened. The Gao Yue/Zhou Wei team and the Hong Kong Baptist University/Shanghai Jiao Tong University Lu Haitao team conducted proteomics research and successfully constructed a panoramic plasma proteomics molecular map of plateau myocardial injury. Through multi-modal machine learning and data visualization analysis, a total of 134 potential differential proteins were identified. Bai, further research determined that ITGA2B is a key functional protein that regulates heart health at plateau. Overexpression of this protein under hypoxic conditions will aggravate the structural and functional damage of the heart, and confirmed that tanshinone IIA is expected to become a new candidate drug molecule that targets and antagonizes hypoxic myocardial damage.

　　Author information: Academician Gao Yue, Associate Researcher Zhou Wei, and Researcher Lv Haitao are the co-corresponding authors. Core units: Institute of Radiation Medicine, Academy of Military Medical Sciences, Institute of Systems Biomedicine, Shanghai Jiao Tong University.

　　Introduction to Academician Gao Yue:

　　Academician Gao Yue, female, born in December 1963, Han nationality, native of Yixing, Jiangsu Province, member of the Communist Party of China, expert in traditional Chinese medicine pharmacology, academician of the Chinese Academy of Engineering, academician of the International Eurasian Academy of Sciences, director, researcher, and doctoral supervisor of the Pharmacology and Toxicology Research Office of the Institute of Radiation and Radiation Medicine, Academy of Military Medical Sciences. Gao Yue studied at Jiangxi University of Traditional Chinese Medicine from 1980 to 1985; received a master's degree in medicine from Tianjin University of Traditional Chinese Medicine in 1988; received a doctorate in medicine from the Academy of Military Medical Sciences of the Chinese People's Liberation Army in 2004; and was elected as an academician of the International Eurasian Academy of Sciences in 2016. ; In December 2018, he was awarded the Qihuang Scholar of the "Hundreds and Thousands" Talent Project (Qihuang Project) for the Inheritance and Innovation of Traditional Chinese Medicine. In November 2025, he was elected as an academician of the Chinese Academy of Engineering. He is mainly engaged in research work such as preclinical evaluation of new drugs, pharmacology and toxicology of traditional Chinese medicine, and modernization of traditional Chinese medicine compounds.