动物造模,动脉粥样硬化模型 z-bio 2023-10-13 757

　　1. Animal modeling material: Rabbit, regardless of gender; Medication: Norepinephrine.

　　2. Method of modeling: Animals were injected with 1mg/d of norepinephrine intravenously for 30 minutes. Or drip for 15 minutes first,

　　Rest for 5 minutes and then drip for another 15 minutes. Or drip for 5 minutes each time and rest for 5 minutes, repeating 6 times. Lasting for two weeks.

　　3. Modeling principle: Catechol drugs cause atherosclerosis in animals.

　　4. Changes after modeling: After modeling, the animal's aorta showed lesions, showing elongation, splitting, or rupture of elastic fibers in the middle layer of the vascular wall, and necrosis and calcification in the lesions.