动物造模,酒精致慢性肝损伤 zi-bio 2024-01-09 1594

　　1. Animal modeling materials: Wistar rats, weighing 250-300g, regardless of gender; Medication: Alcoholic liquid feed containing sufficient nutrients (alcohol accounts for 47% of total calories); Instruments: gastric tube, micro infusion pump.

　　2. The modeling method involves implanting a long-term gastric tube into rats during surgery, and continuously injecting alcohol liquid feed containing sufficient nutrients with a micro infusion pump for 24 hours.

　　3. Principle of modeling: Liver damage caused by alcohol.

　　4. Changes after modeling: Rats in the modeling group showed hepatic steatosis, hepatocyte degeneration, necrosis, and inflammation. Liver fibrosis can occur at 12-16 weeks, which is consistent with the pathological process of progressive alcoholic liver disease in humans