动物造模,慢性肝损伤 zi-bio 2024-01-09 1393

　　1. Animal modeling materials: Rats, weighing 200-250g, regardless of gender; Medication: carbonyl iron, Lieber Decarli liquid feed.

　　2. Modeling method: Carbonyl iron (2.5g/L) was added to Lieber Decarli liquid feed, and rats in the same litter were paired and fed for 12 weeks.

　　3. Principle of modeling: Liver damage caused by carbonyl iron and alcohol.

　　4. Changes after modeling: In addition to hepatic steatosis, the model rats also showed mild peripheral fibrosis of the central vein. It was also found that the content of malondialdehyde and hydroxyproline in liver tissue increased, indicating that liver lipid peroxidation caused liver fibrosis.