动物造模,牵张成骨大鼠实验模型 zi-bio 2024-03-04 546

　　Objective: To establish a novel method for tibial distraction osteogenesis in SD rats

　　Method: Forty male SD rats were subjected to right tibia osteotomy and shortened by 4mm. A self-designed circular traction external fixator was used for fixation. During the fracture repair period, the traction external fixator was used to restore the height of the tibia. After surgery, the healing and recovery of the osteotomy site were observed through gross observation, imaging observation, and histological methods

　　Result: The external fixator was stable and effective after surgery, and had no significant impact on the functional activity of rats. The tibial height recovered and bone healing occurred

　　Conclusion: The rat tibial distraction osteogenesis model established in the experiment is reliable, practical, and reproducible