动物造模,慢性支气管炎,药效评价 zi-bio 2024-05-16 512

　　Method 1

　　1. Animal modeling materials: mice, weighing 18-25g; Drug: S0:; Equipment: fumigation box.

　　2. Modeling method: Model mice were induced to inhale 2% SO2 for 10 seconds per day for 60 days.

　　3. The principle of modeling is to establish a chronic bronchitis model by inhaling SO2 to cause tracheal injury and inflammation in animals.

　　4. Changes after modeling: Bronchial lesions appeared 14 to 18 days after modeling, and severe tracheitis lesions appeared 27 days later.

　　Method 2

　　1. Animal modeling materials: mice, weighing 18-25g; Medication: SO2; Equipment: fumigation box.

　　2. Modeling method: Model mice were induced to inhale 1% SO2 for 20 seconds per day for 25 days.

　　3. The principle of modeling is to establish a chronic bronchitis model by inhaling SO2 to cause tracheal injury and inflammation in animals.

　　4. Changes after modeling: Chronic bronchitis lesions appeared after 20 days of modeling.