动物造模,药效评价,负压性脑创伤 z-bio 2024-09-25 458

　　The negative pressure traumatic brain injury model established by Mahmood et al. mainly consists of a stent, straw, syringe tube, spring coil, pressure sensing transducer, oscilloscope, etc. When the syringe tube retracts due to the tension of the spring, the negative pressure generated is transmitted to the opening of the straw. As the opening of the straw is sealed by the rat dura mater, the negative pressure acts on the dura mater and the underlying brain tissue, causing damage to the brain tissue. The pressure is expressed as a visible pressure wave through the sensor on the oscilloscope. This model has clear tissue damage caused by negative pressure injury, and the resulting damage is limited to the cortex and subcortical local tissues at the site of negative pressure impact. This model is suitable for the study of focal superficial traumatic brain injury. Not suitable for studying animal cognition and motor function.