支气管扩张症 z-bio 2025-02-05 565

Characteristic Map of Chinese Branch Expansion Patients

　　With the support of National Natural Science Foundation of China projects (approval numbers: 81925001, 82330070) and other grants, the team of Professor Xu Jinfu from Fudan University Affiliated East China Hospital/Tongji University Respiratory Disease Research Institute, and Professor Qu Jieming from Shanghai Jiao Tong University School of Medicine Affiliated Ruijin Hospital, together with domestic and foreign scholars, have made progress in the clinical feature map data of patients with bronchiectasis (referred to as bronchiectasis) in China. The research findings were published on January 10, 2024 in The Lancet Respiratory Medicine, under the title "Baseline characteristics of patients in the Chinese Bronchiactasis Registry [BE China]: a multicenter prospective cohort study". Paper link: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600 (24)00364-3/fulltext。

　　Bronchiectasis is a chronic airway disease, and its incidence rate is increasing year by year. Branch expansion has the characteristics of long disease course, significant symptoms, and easy recurrence of acute exacerbation. However, currently there is limited understanding of the clinical characteristics of Chinese patients with bronchiectasis, and there is a lack of systematic collection and analysis of data on the population of bronchiectasis patients. Clarifying the clinical characteristics and heterogeneity of Chinese patients with bronchiectasis is a key issue in improving the standardized diagnosis and treatment capabilities of bronchiectasis in China.

　　The research team collected clinical data from 10324 patients with branch expansion from 97 centers and compared it with the characteristics of branch expansion cohorts such as the European Branch Expansion Alliance. Research has found that women account for a higher proportion of patients with bronchiectasis in China and are more likely to develop cardiovascular disease and chronic obstructive pulmonary disease. In terms of lung function, obstructive airflow limitation is the main type, accounting for 42.8%. Etiological analysis shows that infection is the most common factor leading to bronchiectasis, accounting for 43.2%; Pseudomonas aeruginosa is the pathogen with the highest detection rate, accounting for 20.8%. The imaging examination results showed that cystic bronchiectasis was the most common manifestation, accounting for 37.4%. In addition, the study also found that patients with branch expansion in low - and middle-income areas have a heavier disease burden, higher rates of acute exacerbation and hospitalization, and poorer quality of life.

　　This study established the Chinese Bronchiectasis Registry (BE China) and drew a clinical characteristic map of bronchiectasis patients in China, revealing their distinct regional features. The research results provide data support for the precise diagnosis and treatment of branch expansion.