牛磺酸抗衰研究,牛磺酸,抗衰 z-bio 2025-07-03 2750

　　Taurine, a common ingredient in energy drinks and health products, was once regarded as an "anti-aging new star".

　　In June 2023, the National Institute of Immunology in India and Columbia University in the United States published a paper in Science, saying that as you get older, the taurine levels in mice, monkeys and humans will decrease, and daily taurine supplementation can prolong the lifespan of defective mice and improve their health, and can even extend the healthy lifespan of middle-aged mice by 12%. This conclusion quickly makes taurine a "net celebrity ingredient" in the field of anti-aging.

　　The results of this study show that taurine supplementation can slow down the aging of nematodes, mice and monkeys. This discovery has rekindled interest in taurine as a potential biomarker of aging, a driver of aging and a therapeutic target for aging.

　　However, on June 5, 2025, the research team of the National Institute of Aging of the National Institutes of Health published an article titled "Is taurine an aging biomarker?" in the same journal, directly questioning the conclusions of the article published in 2023 and raising questions about the use of taurine as a biomarker of aging and its use as a dietary supplement.

　　The National Institutes of Health research design covers longitudinal and cross-sectional evaluation of taurine concentrations in humans, non-human primates (NHPs) and mice, measuring the changes in taurine concentrations with age in these species and assessing their relationship with functional indicators of health status (such as muscle strength and weight).

　　The results show that in healthy humans, non-human primates and mice, the concentration of taurine does not decrease with age, but will instead rise or remain unchanged.

　　Among them, in the Baltimore Longitudinal Aging Study (BLSA) cohort of humans, taurine concentrations in women increased linearly with age, while men showed nonlinear increase; in the Balearic cohort, taurine concentrations in women increased exponentially with age, while men showed linear increase. In nonhuman primates, the taurine level in females and males increases with age. In mice, the taurine level in female animals increased with age, while the males remained the same.

　　Moreover, the variability of taurine concentration among individuals is usually greater than the longitudinal change with age, which limits its utility as a biomarker of aging. The relationship between taurine concentration and health status functional indicators also varies by age, species, and cohort, showing inconsistency. In the human longitudinal cohort study, taurine concentration was positively correlated with knee strength regardless of gender, but not significantly correlated with grip strength, similar situations occurred in the mouse study. The relationship between taurine concentration and weight in humans. Before middle age, taurine concentration is positively correlated with body weight. When it reaches a very old stage (such as 90 years old), this relationship may disappear or even reverse. In the longitudinal study of primates and mice, the relationship between taurine concentration and body weight showed different trends of change.

　　Based on these findings, researchers believe that changes in circulating taurine concentration are not a common feature of aging, there is no obvious association between taurine concentration and aging, and there is no direct evidence to support the idea that a decrease in this indicator will promote aging phenotype.

　　The article says that as long as you maintain a healthy diet, you don’t need to supplement your taurine. However, the research team also said that it does not question the possibility of taurine deficiency leading to more effects such as aging, and further exploration is needed in the future.

　　In the field of scientific research, it is not uncommon for new research to overturn old views. For example, in cardiovascular disease research, early studies felt that intake of large amounts of vitamin E supplements can reduce the risk of heart attacks, but subsequent in-depth and rigorously designed studies have shown that vitamin E supplements do not have such effects, and may even have adverse effects in some cases.

　　Science is moving forward in this process of constant doubt, research, re-question and re-research. Every update of opinions brings us closer to the truth of things.